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1

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

Maiti, Munmun, Maiti, Mohitosh, Rozenski, Jef, De Jonghe, Steven, Herdewijn, Piet

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 550 KB

english, 2015

2

Current Protocols in Nucleic Acid Chemistry || Analysis and Purification of Synthetic Nucleic Acids Using HPLC

Egli, Martin, Herdewijn, Piet, Matusda, Akira, Sanghvi, Yogesh S.

Year:

2001

Language:

english

File:

PDF, 1.16 MB

english, 2001

3

Current Protocols in Nucleic Acid Chemistry || Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 274 KB

english, 2001

4

Current Protocols in Nucleic Acid Chemistry || DNA Synthesis Without Base Protection

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 360 KB

english, 2001

5

Current Protocols in Nucleic Acid Chemistry || Introduction to the Synthesis and Purification of Oligonucleotides

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 217 KB

english, 2001

6

Synthesis and Structure-Activity Relationship Studies of 2-(1,3,4-Oxadiazole-2(3 H )-thione)-3-amino-5-arylthieno[2,3- b ]pyridines as Inhibitors of DRAK2

Leonczak, Piotr, Gao, Ling-Jie, Ramadori, Anna Teresa, Lescrinier, Eveline, Rozenski, Jef, De Jonghe, Steven, Herdewijn, Piet

Journal:

Year:

2014

Language:

english

File:

PDF, 420 KB

english, 2014

7

Nucleic Acids with a Six-Membered ‘Carbohydrate’ Mimic in the Backbone

Journal:

Chemistry & Biodiversity

Year:

2010

Language:

english

File:

PDF, 2.51 MB

english, 2010

8

Synthesis and Antibacterial Evaluation of a Novel Series of 2-(1,2-Dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

Alessandro Stella, Kenneth Segers, Steven De Jonghe, Bart Vanderhoydonck, Jef Rozenski, Jozef Anné, Piet Herdewijn

Journal:

Chemistry & Biodiversity

Year:

2011

Language:

english

File:

PDF, 206 KB

english, 2011

9

Influence of the Nucleobase and Anchimeric Assistance of the Carboxyl Acid Groups in the Hydrolysis of Amino Acid Nucleoside Phosphoramidates

Munmun Maiti, Servaas Michielssens, Dr. Natalia Dyubankova, Mohitosh Maiti, Prof. Dr. Eveline Lescrinier, Prof. Dr. Arnout Ceulemans, Prof. Dr. Piet Herdewijn

Journal:

Chemistry - A European Journal

Year:

2012

Language:

english

File:

PDF, 764 KB

english, 2012

10

Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety

A. Van Aerschot, G. Schepers, R. Busson, J. Neyts, E. De Clercq, P. Herdewijn

Journal:

Year:

2004

File:

PDF, 55 KB

2004

11

Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

María-Jesús Pérez-Pérez, Erik De Clercq, Piet Herdewijn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 210 KB

english, 1996

12

Synthesis and Evaluation of 6-Aza-2′-deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis

Martin Kögler, Roger Busson, Steven De Jonghe, Jef Rozenski, Kristien Van Belle, Thierry Louat, Hélène Munier-Lehmann, Piet Herdewijn

Journal:

Chemistry & Biodiversity

Year:

2012

Language:

english

File:

PDF, 787 KB

english, 2012

13

Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2′-deoxyuridines

Isabelle Creuven, Christine Evrard, Anne Olivier, Guy Evrard, Arthur Van Aerschot, Piet Wigerinck, Piet Herdewijn, Francois Durant

Journal:

Antiviral Research

Year:

1996

Language:

english

File:

PDF, 643 KB

english, 1996

14

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Jan Paeshuyse, Carine Letellier, Matheus Froeyen, Hélène Dutartre, Robert Vrancken, Bruno Canard, Erik De Clercq, Alain Gueiffier, Jean-Claude Teulade, Piet Herdewijn, Gerhard Puerstinger, Frank Koene

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 407 KB

english, 2009

15

Ajuga remota Benth.: From ethnopharmacology to phytomedical perspective in the treatment of malaria

K. Cocquyt, P. Cos, P. Herdewijn, L. Maes, P.E. Van den Steen, G. Laekeman

Journal:

Year:

2011

Language:

english

File:

PDF, 839 KB

english, 2011

16

5-chloro-substituted derivatives of 2',3'-didehydro-2' ,3'-dideoxyuridine, 3'-fluoro-2' ,3'-dideoxyuridine and 3'-azido-2' ,3'-dideoxyuridine as anti-HIV agents

Jan Balzarini, Arthur Van Aerschot, Piet Herdewijn, Erik De Clercq

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 574 KB

english, 1989

17

Current Protocols in Nucleic Acid Chemistry || RNA Synthesis by Reverse Direction Process: Phosphoramidites and High Purity RNAs and Introduction of Ligands, Chromophores, and Modifications at 3′-End

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 1.57 MB

english, 2001

18

2′-Azido-2′,3′-dideoxythymidine: Synthesis and crystal structure of a 2′-substituted dideoxynucleoside

A. Van Aerschot, D. Everaert, G. Gosselin, O. Peeters, N. Blaton, C. De Ranter, J.-L. Imbach, J. Balzarini, E. De Clercq, P. Herdewijn

Journal:

Antiviral Research

Year:

1990

Language:

english

File:

PDF, 685 KB

english, 1990

19

Dipeptides as Leaving Group in the Enzyme-Catalyzed DNA Synthesis

Song, Xiao-Ping, Bouillon, Camille, Lescrinier, Eveline, Herdewijn, Piet

Journal:

Chemistry & Biodiversity

Year:

2012

Language:

english

File:

PDF, 495 KB

english, 2012

20

Synthesis, and in vitro Enzymatic and Antiviral Evaluation of d4T Polyphosphate Derivatives as Chain Terminators

Yang, Shiqiong, Pannecouque, Christophe, Herdewijn, Piet

Journal:

Chemistry & Biodiversity

Year:

2012

Language:

english

File:

PDF, 486 KB

english, 2012

21

Current Protocols in Nucleic Acid Chemistry || Nucleic Acid Structure Characterization by Small Angle X-Ray Scattering (SAXS)

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 565 KB

english, 2001

22

Current Protocols in Nucleic Acid Chemistry || Rapid and Efficient Synthesis of Nucleoside Polyphosphates and Their Conjugates Using Sulfonyl Imidazolium Salts

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 586 KB

english, 2001

23

Current Protocols in Nucleic Acid Chemistry || Common Buffers and Stock Solutions

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 107 KB

english, 2001

24

Current Protocols in Nucleic Acid Chemistry || Attachment of Nucleosides and Other Linkers to Solid-Phase Supports for Oligonucleotide Synthesis

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 504 KB

english, 2001

25

Heterocyclic Modifications of Oligonucleotides and Antisense Technology

Herdewijn, Piet

Journal:

Antisense and Nucleic Acid Drug Development

Year:

2000

Language:

english

File:

PDF, 333 KB

english, 2000

26

Current Protocols in Nucleic Acid Chemistry || Modification of the 5�� Terminus of Oligonucleotides for Attachment of Reporter and Conjugate Groups

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 442 KB

english, 2001

27

Current Protocols in Nucleic Acid Chemistry || Synthesis of Alkyne- and Azide-Modified Oligonucleotides and Their Cyclization by the CuAAC (Click) Reaction

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 401 KB

english, 2001

28

Current Protocols in Nucleic Acid Chemistry || Convenient and Efficient Approach to the Permanent or Reversible Conjugation of RNA and DNA Sequences with Functional Groups

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 738 KB

english, 2001

29

Current Protocols in Nucleic Acid Chemistry || Safe Deprotection Strategy for the Tert-Butyldimethylsilyl (TBS) Group During RNA Synthesis

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 601 KB

english, 2001

30

Synthesis and Anti-herpetic Activity of Phosphoramidate ProTides

Maiti, Munmun, Persoons, Leentje, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Herdewijn, Piet

Journal:

Year:

2013

Language:

english

File:

PDF, 526 KB

english, 2013

31

Current Protocols in Nucleic Acid Chemistry || Oligoribonucleotides with 2��- O -( tert -Butyldimethylsilyl) Groups

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 214 KB

english, 2001

32

A Synthetic Substrate of DNA Polymerase Deviating from the Bases, Sugar, and Leaving Group of Canonical Deoxynucleoside Triphosphates

Jang, Mi-Yeon, Song, Xiao-Ping, Froeyen, Mathy, Marlière, Philippe, Lescrinier, Eveline, Rozenski, Jef, Herdewijn, Piet

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 752 KB

english, 2013

33

Current Protocols in Nucleic Acid Chemistry || Design, Synthesis, and Amplification of DNA Pools for In Vitro Selection

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 582 KB

english, 2001

34

Tailoring Peptide-Nucleotide Conjugates (PNCs) for Nucleotide Delivery in Bacterial Cells

De, Swarup, Groaz, Elisabetta, Herdewijn, Piet

Journal:

European Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

35

Current Protocols in Nucleic Acid Chemistry || A Simple Chemical Synthesis of Sugar Nucleoside Diphosphates in Water

Egli, Martin, Herdewijn, Piet, Matusda, Akira, Sanghvi, Yogesh S.

Year:

2001

Language:

english

File:

PDF, 603 KB

english, 2001

36

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

Wang, Jing, Verbeure, Birgit, Luyten, Ingrid, Lescrinier, Eveline, Froeyen, Matthias, Hendrix, Chris, Rosemeyer, Helmut, Seela, Frank, Van Aerschot, Arthur, Herdewijn, Piet

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

37

Current Protocols in Nucleic Acid Chemistry || 2′-Hydroxy Protection of Ribonucleosides as 2-Cyano-2,2-Dimethylethanimine- N -Oxymethyl Ethers in Solid-Phase Synthesis of RNA Sequences

Egli, Martin, Herdewijn, Piet, Matusda, Akira, Sanghvi, Yogesh S.

Year:

2001

Language:

english

File:

PDF, 843 KB

english, 2001

38

Current Protocols in Nucleic Acid Chemistry || Nucleobase Protection of Deoxyribo- and Ribonucleosides

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 253 KB

english, 2001

39

Current Protocols in Nucleic Acid Chemistry || Synthesis of Oligodeoxyribo- and Oligoribonucleotides According to the H -Phosphonate Method

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 131 KB

english, 2001

40

Current Protocols in Nucleic Acid Chemistry || Oligodeoxyribonucleotide Analogs Functionalized with Phosphonoacetate and Thiophosphonoacetate Diesters

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 325 KB

english, 2001

41

1,5-Anhydro-2-Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna

Allart, Brigitte, Van Aerschot, Arthur, Herdewijn, Piet

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 211 KB

english, 1998

42

Oligonucleotide Synthesis Volume 288 ||

Herdewijn, Piet

Year:

2004

Language:

english

File:

PDF, 6.72 MB

english, 2004

43

Current Protocols in Nucleic Acid Chemistry || Deoxyribo- and Ribonucleoside H -Phosphonates

Beaucage, Serge L., Bergstrom, Donald E., Herdewijn, Piet, Matsuda, Akira

Year:

2001

Language:

english

File:

PDF, 167 KB

english, 2001

44

Oligonucleotide Synthesis Volume 288 || Dimethylthiarum Disulfide: New Sulfur Transfer Reagent in Phosphorothioates Oligonucleotide Synthesis

Herdewijn, Piet

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

45

1′,5′-Anhydro- l - ribo -hexitol Adenine Nucleic Acids (α- l -HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World

D’Alonzo, Daniele, Froeyen, Mathy, Schepers, Guy, Di Fabio, Giovanni, Van Aerschot, Arthur, Herdewijn, Piet, Palumbo, Giovanni, Guaragna, Annalisa

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 1.93 MB

english, 2015

46

Lipophilic nalmefene prodrugs to achieve a one-month sustained release

Gaekens, Tim, Guillaume, Michel, Borghys, Herman, De Zwart, Loeckie L., de Vries, Ronald, Embrechts, Roger C.A., Vermeulen, An, Megens, Anton A.H.P., Leysen, Josée E., Herdewijn, Piet, Annaert, Pieter

Journal:

Journal of Controlled Release

Year:

2016

Language:

english

File:

PDF, 601 KB

english, 2016

47

Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

Bigan, Erwan, Mattelaer, Henri-Philippe, Herdewijn, Piet

Journal:

Journal of Molecular Evolution

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

48

Current Protocols in Nucleic Acid Chemistry || C-C Bond Formation: Synthesis of C5 Substituted Pyrimidine and C8 Substituted Purine Nucleosides Using Water Soluble Pd-imidate Complex

Egli, Martin, Herdewijn, Piet, Matusda, Akira, Sanghvi, Yogesh S.

Year:

2001

Language:

english

File:

PDF, 581 KB

english, 2001

49

Synthesis and in Vitro Antiviral Activities of [(Dihydrofuran-2-yl)oxy]methyl-phosphonate Nucleosides with 2-Substituted Adenine as Base

Liu, Fei, Liu, Yingju, Xu, Rui-Gang, Dai, Guifu, Zhao, Liu-Xi, Wang, Yafeng, Liu, Hong-Min, Liu, Feng-Wu, Pannecouque, Christophe, Herdewijn, Piet

Journal:

Chemistry & Biodiversity

Year:

2015

Language:

english

File:

PDF, 385 KB

english, 2015

50

Current Protocols in Nucleic Acid Chemistry || Solid-Phase Synthesis of DNA and RNA 5′- O -Triphosphates Using cyclo Sal Chemistry

Egli, Martin, Herdewijn, Piet, Matusda, Akira, Sanghvi, Yogesh S.

Year:

2001

Language:

english

File:

PDF, 327 KB

english, 2001